Selective Depression of Sympathetic Transmission by Intravenous Administration of Iproniazid and Harmine.

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Abstract
Large intravenous doses of 2 monoamine oxidase inhibitors, iproniazid (100-175 mg/kg) and harmine (5-15 mg/kg) decreased transmission through the stellate ganglion of the anesthetized dog. Depression of transmission was determined by pronounced decrements in the degree of tachycardia produced by preganglionic stimulation after administration of the inhibitor. Effects produced by post-ganglionic and vagal stimulation were not decreased by the inhibitors. Similar results were obtained in cats after administration of iproniazid (50-100 mg/kg). Transmission was studied in the cat by recording contractions of the nictitating membrane produced by stimulating the pre- and postganglionic nerves of the superior cervical ganglion. The implications of these results are discussed.