Predicted impact of intravenous thrombolysis

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# Patients who died or recovered fully should have been included in analysis {#article-title-2} EDITOR—Jørgensen et al report a simulation of the impact of intravenous thrombolysis on prognosis for a general population of stroke patients.1 Although we do not argue with their conclusion that comparatively few patients with acute ischaemic stroke will benefit from thrombolytic treatment, we believe that their analysis of the data is flawed. During their retrospective analysis Jørgensen et al identified patients who fulfilled the criteria for thrombolysis and then excluded patients who died or had a full recovery. They subsequently excluded the same groups of patients from the ideal scenario in which all patients were admitted within the time window for thrombolysis. Had thrombolysis actually been given, the outcomes for these patients would have been unknown at the time of administration. These patients should therefore have been included in the analysis. 1. 1.↵1. Jørgensen HS, 2. Nakayama H, 3. Kammersgaard LP, 4. Raaschou HO, 5. Olsen TS . Predicted impact of intravenous thrombolysis on prognosis of general population of stroke patients: simulation model. BMJ 1999; 319: 288–289. (31 July.) [OpenUrl][1][FREE Full Text][2] # Another trial is needed {#article-title-4} EDITOR—The paper by Jørgensen et al provides a small counterbalance to the enormous propaganda behind an expensive, minimally tested, and potentially harmful intervention.1 The real ratio of benefit to risk of thrombolytics for stroke may even be far worse than Jørgensen et al calculate, for the following reasons. Firstly, even fewer … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DJorgensen%26rft.auinit1%253DH.%2BS.%26rft.volume%253D319%26rft.issue%253D7205%26rft.spage%253D288%26rft.epage%253D289%26rft.atitle%253DPredicted%2Bimpact%2Bof%2Bintravenous%2Bthrombolysis%2Bon%2Bprognosis%2Bof%2Bgeneral%2Bpopulation%2Bof%2Bstroke%2Bpatients%253A%2Bsimulation%2Bmodel%26rft_id%253Dinfo%253Apmid%252F10426737%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=FULL&journalCode=bmj&resid=319/7205/288&atom=%2Fbmj%2F320%2F7240%2F1006.atom

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