Effects of morphine on human pancreatic secretion: studies on pure pancreatic juice.

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Abstract
Data concerning the effects of morphine on human pancreatic secretion are fragmentary and inconclusive. In the present study, the effects of morphine on pure pancreatic secretion in 9 subjects with external transduodenal drainage of the main pancreatic duct, performed after biliary tract surgery, were evaluated. I.v. infusion of a small dose of morphine, 40 .mu.g/kg per h, during pancreatic stimulation with secretin and cholecystokinin, caused a significant increase in volume, bicarbonate and Ca secretion, and a significant decrease in protein secretion. The stimulatory effect on water and electrolyte secretion was rapid and much more pronounced, reaching .apprx. 45-50% of the control levels; however the inhibition of protein output was slightly delayed and of lesser magnitude, reaching .apprx. 20-25% of the control values. Both effects were long-lasting. The addition of naloxone, a potent opiate antagonist, prevented in part the effects of morphine on pancreatic secretion, suggesting that specific opiate receptors might be involved in these effects.