Isometric dynamic response of mammalian heart muscle due to step changes in the calcium concentration of the perfusing medium.
- 26 May 1976
- journal article
- Vol. 11, 159-67
Abstract
The isometric tension transient response of isolated kitten papillary muscle was found to exhibit direction-dependent dynamics when subjected to step changes in the calcium concentration of the bathing medium. The tension transient curves could be resolved into a minimum of two to three exponential components, which could be considered to indicate different calcium compounds or compartments within the muscle. However, a model relating calcium diffusion across the muscle to the dose-response curve indicates that the exponential components of the tension transient curves are due to the properties of calcium diffusion through the extracellular space, and that the direction-dependent dynamics are caused by the nonlinearity of the dose-response curve.This publication has 0 references indexed in Scilit: