New pleuromutilin derivatives with enhanced antimicrobial activity. I. Synthesis.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (9) , 915-922
- https://doi.org/10.7164/antibiotics.29.915
Abstract
A series of new derivatives of the antibiotic pleuromutilin, produced by some Basidiomycetes, was synthesized by chemical modification of natural pleuromutilin. Most of them contain basic functional groups in the side chain at C14 of the mutilin skeleton. The monotosylate of pleuromutilin was used as a versatile intermediate for displacement by N-, O- and S-nucleophiles.This publication has 0 references indexed in Scilit: