Organ Culture of the 16th Gestation Day Mouse Labyrinth:A Model Suggestion for Pre- and Post-partum Development

Abstract
The 16th day mouse embryo inner ear was ex-planted and cultured “in vitro” for 6 days, which corresponds to 1 day post-partum development “in vivo”. A normal development occurred both when the inner ear anlage was divided into a vestibular and a cochlear portion and when it was cultured as a whole. The present model system may provide a helpful tool in the study of both normal development and inner ear pathology.

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