A PRELIMINARY STUDY ON THE INTERFERON-α TREATMENT FOR XEROSTOMIA OF SJÖGREN'S SYNDROME
- 1 January 1993
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 32 (1) , 52-54
- https://doi.org/10.1093/rheumatology/32.1.52
Abstract
We studied the therapeutic effect of interferon-α on the xerostomia of Sjögren's syndrome by injecting 1×106 units of interferon-α intramuscularly once weekly. Saliva production was quantitated by the Saxon test. Variation of saliva production measured at monthly intervals during the 3-month period prior to administration of interferon-α was within ±0.30 g/2 min. After administration of interferon-α, saliva production increased to greater than 0.30 g/2 min in six patients, and the increase was statistically significant by the paired t-test (P=0.002). The result suggests a beneficial effect of this agent in increasing the saliva production of patients with primary Sjögren's syndrome.Keywords
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