Immunological mutants of the mouse
- 1 July 1991
- journal article
- review article
- Published by Wiley in Journal of Anatomy
- Vol. 191 (3) , 303-311
- https://doi.org/10.1002/aja.1001910310
Abstract
Mutations at more than 30 loci in mice have been shown to cause deleterious effects on the immune system. Immunologic defects caused by certain of these mutations are determined at the level of hematopoietic progenitor cells or at the level of hematopoietic cell‐stromal cell interactions. The immunological mutants described in this paper serve as experimental tools with which to increase our understanding of the development and regulation of the mammalian immune system.Keywords
This publication has 71 references indexed in Scilit:
- The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombinationCell, 1988
- The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanismCell, 1988
- The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement.Genes & Development, 1988
- Phagocyte defectsClinical Immunology and Immunopathology, 1986
- Evaluation of the mouse mutant “wasted” as an animal model for ataxia telangiectasiaMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1986
- Expression of an X-linked gene family (XLR) in late-stage B cells and its alteration by the xid mutationNature, 1985
- Isolation of a cDNA clone corresponding to an X-linked gene family (XLR) closely linked to the murine immunodeficiency disorder xidNature, 1985
- Plasma corticosterone concentrations in diabetic (db) miceDiabetologia, 1977
- Relationship between the adrenal cortex and thymic involution in “lethargic” mutant miceJournal of Anatomy, 1976
- Hereditary Absence of Spleen in the MouseNature, 1959