The Challenge of HIV-1 Subtype Diversity
Top Cited Papers
- 10 April 2008
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 358 (15) , 1590-1602
- https://doi.org/10.1056/nejmra0706737
Abstract
HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as classifiable into distinct subtypes needs to reflect the reality of the constant emergence of new strains. This review discusses the implications of subtype diversity in HIV-1 for possible differential rates of disease progression, responses to antiretroviral therapy (including the development of resistance), and vaccine development.Keywords
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