High Frequencies of a Rearrangement (+ATA; -T) at -530 to the β-Globin Gene in Different Populations Indicate the Absence of a Correlation with a Silent β-Thalassemia Determinant
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 13 (1) , 1-5
- https://doi.org/10.3109/03630268908998048
Abstract
DNA samples from numerous subjects of different racial and ethnic backgrounds, with or without various hemoglobinopathies (classical .beta.-thalassemia; silent .beta.-thalassemia, Hb E, sickle cell anemia), were studied for a rearrangement (+ATA; -T) at nucleotide -530 in the 5'' flanking region of the .beta.-globin gene using amplified DNA and 32P-labeled synthetic oligonucleotide probes. The data show that this unusual sequence is a common feature among East-Asians and Blacks (particularly SS patients), and is not associated with mild thalassemic features typical for the silent form of .beta.-thalassemia, as has been suggested (5).This publication has 6 references indexed in Scilit:
- Haplotypes of βSChromosomes Among Patients with Sickle Cell Anemia from GeorgiaHemoglobin, 1986
- The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regionsCell, 1984
- Detection of a novel DNA polymorphism in the beta-globin gene cluster.Journal of Biological Chemistry, 1984
- Construction of Human Gene Libraries from Small Amounts cf Peripheral Blood: Analysis of β-Like Globin GenesHemoglobin, 1981
- Different Types of Beta-Thalassemia IntermediaActa Haematologica, 1978
- The Silent Carrier of Beta ThalassemiaNew England Journal of Medicine, 1969