Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin
- 12 March 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 283 (5408) , 1739-1742
- https://doi.org/10.1126/science.283.5408.1739
Abstract
Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of β-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila .Keywords
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