Availability of unrelated donors for hematopoietic stem cell transplantation for hemoglobinopathies
- 1 April 2003
- journal article
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 31 (7) , 547-550
- https://doi.org/10.1038/sj.bmt.1703887
Abstract
Hematopoietic stem cell transplantation (HSCT) is the only curative option for patients with hemoglobinopathies. However, fewer than 30% of individuals will have an HLA-identical sibling. Improvement in outcomes after HSCT using unrelated donors (URD), and the development of novel nontoxic preparative regimens may make URD HSCT an option for hemoglobinopathy patients who do not have an HLA-identical sibling donor. The National Marrow Donor Program (NMDP) maintains a Registry of 4 million volunteer donors, and facilitates URD HSCT for patients with life-threatening blood diseases. In light of the increased representation of minorities in the NMDP registry, donor searches were run in April 2001 for a cohort of 272 thalassemia patients and 77 sickle cell disease (SCD) patients for whom searches had been submitted between 1989 and 2001 in order to determine the current likelihood of finding a potential donor of hematopoietic stem cells for hemoglobinopathy patients. About 59.7% SCD patients 80.2% thalassemia patients will find at least one potential 6/6 HLA matched donor or umbilical cord blood (UCB) unit. All patients will find at least one donor or UCB that is a potential 5/6 HLA match. In conclusion the majority of hemoglobinopathy patients will find at least one potential HLA matched unrelated bone marrow donor or UCB.Keywords
This publication has 15 references indexed in Scilit:
- Successful Matched-Unrelated Bone Marrow Transplantation in a Patient With Beta-Thalassemia MajorJournal of Pediatric Hematology/Oncology, 2002
- Unrelated donor bone marrow transplantation for thalassemia: the effect of extended haplotypesBlood, 2002
- Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimenBlood, 2002
- Hematopoietic stem cell transplantation after reduced-intensity conditioning as treatment of sickle cell diseaseExperimental Hematology, 2002
- Establishment of complete and mixed donor chimerism after allogeneic lymphohematopoietic transplantation: Recommendations from a workshop at the 2001 Tandem Meetings of the International Bone Marrow Transplant Registry and the American Society of Blood and Marrow TransplantationTransplantation and Cellular Therapy, 2001
- Equivalent outcomes in patients with chronic myelogenous leukemia after early transplantation of phenotypically matched bone marrow from related or unrelated donorsThe American Journal of Medicine, 2001
- Bone Marrow Transplantation without Myeloablation for Sickle Cell DiseaseNew England Journal of Medicine, 2001
- Bone marrow transplantation from alternative donors for thalassemia: HLA-phenotypically identical relative and HLA-nonidentical sibling or parent transplantsBone Marrow Transplantation, 2000
- Trasplante de médula ósea de donante no emparentado en una niña con talasemia mayorMedicina Clinica, 2000
- Unrelated and HLA-Nonidentical Related Donor Marrow Transplantation forThalassemia and Leukemia: A Combined Report from the Seattle Marrow Transplant Team and the International Bone Marrow Transplant RegistryaAnnals of the New York Academy of Sciences, 1998