Renal papillary necrosis after aspirin and alclofenac.

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Abstract
There are reported cases of Renal Papillary necrosis (RPN) from aspirin usage alone, but most epidemiological studies implicate phenacetin as the toxic component. Combined analgesic preparations may be more toxic to the kidneys, as one drug may alter the renal tissue response to the other drug. The authors report a case of radiologically confirmed RPN after the use of aspririn and alclofenac, a combination which has not been implicated in the aetiology of analgesic nephropathy

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