Dopamine and adult neurogenesis
- 2 October 2006
- journal article
- review article
- Published by Wiley in Journal of Neurochemistry
- Vol. 100 (3) , 587-595
- https://doi.org/10.1111/j.1471-4159.2006.04241.x
Abstract
Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we approach a highly controversial question: can the adult human brain use neurogenesis to replace the dopaminergic neurones in the substantia nigra that are lost in Parkinson's disease?Keywords
This publication has 63 references indexed in Scilit:
- Enhanced De Novo Neurogenesis and Dopaminergic Neurogenesis in the Substantia Nigra of 1‐Methyl‐4‐phyenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinson's Disease‐Like MiceThe International Journal of Cell Cloning, 2006
- Intrastriatal Infusion of Liver Growth Factor Stimulates Dopamine Terminal Sprouting and Partially Restores Motor Function in 6-Hydroxydopamine-lesioned RatsJournal of Histochemistry & Cytochemistry, 2006
- Dopamine Specifically Inhibits Forebrain Neural Stem Cell Proliferation, Suggesting a Novel Effect of Antipsychotic DrugsJournal of Neuroscience, 2005
- D3 dopamine receptors do not regulate neurogenesis in the subventricular zone of adult miceNeurobiology of Disease, 2005
- Memory for spatial location in ‘de novo’ parkinsonian patientsNeuropsychologia, 1997
- Neurotransmitter receptors in the proliferative zones of the developing primate occipital lobeJournal of Comparative Neurology, 1995
- Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cellsNeuron, 1994
- Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell lineEuropean Journal of Pharmacology: Molecular Pharmacology, 1994
- Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous SystemScience, 1992
- Evidence for differential DNA endoreplication during the development of a molluscan brainJournal of Neurobiology, 1987