BBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (10) , 1087-1097
- https://doi.org/10.7164/antibiotics.33.1087
Abstract
A complex of the antitumor antibiotic BBM-928 was produced by an actinomycete strain No. G455-101. Four components, BBM-928 A, B, C and D, were isolated in crystalline form and characterized. They were cyclic depsipeptide antibiotics containing a quinoline nucleus as the chromophore. BBM-928 A is a monoacetyl derivative of BBM-928 B and a diacetyl derivative of BBM-928 C. BBM-928 components exhibit antimicrobial activity against gram-positive and acid-fast bacteria. BBM-928 A is highly active in mice against various experimental tumors including leukemia P388, leukemia L1210, melanoma B16, Lewis lung carcinoma and sarcoma 180. BBM-928 B is less active than BBM-928 A and BBM-928 C has no antitumor activity.This publication has 1 reference indexed in Scilit:
- BBM-928, a new antitumor antibiotic complex II. Taxonomic studies on the producing organism.The Journal of Antibiotics, 1980