Protective Effects of Soybean Meal for the Immature Hyperthyroid Rat

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Abstract
Full-fat soybean meal completely counteracted the growth retardation of immature rats fed massive doses of desiccated thyroid or iodinated casein. It did not counteract, however, the attendant reduction in basal metabolic rate. The antithyrotoxic effects of full-fat soybean meal were correlated in part with its fat content. Growth was retarded in hyperthyroid rats fed similar diets but containing low fat soybean flour in place of the high fat soybean meal. The retardation in growth of immature hyperthyroid rats on a diet containing low fat soybean flour was completely counteracted by the administration of either soybean oil, extracted liver residue or crystalline vitamin B12. When immature rats were fed a similar diet but containing casein as the dietary protein, the growth retardation following thyroid feeding was completely counteracted only by extracted liver residue. Soybean oil showed some counteracting activity; vitamin B12 was inactive. Increasing the fat content of the diet augmented significantly the gains in body weight of hyperthyroid rats fed a diet low in fat and containing casein as the dietary protein. Both animal and vegetable fats were active in this respect.