Ovulation induction with low-dose follicle-stimulating hormone in women with the polycystic ovary syndrome

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Abstract
Fifty infertile women with the polycystic ovary syndrome (PCOS) were treated for 66 cycles with low‐dose FSH stimulation starting with 75 IU FSH for two weeks before eventual stepwise increases in the gonadotropin dose occurred. An unifollicular response was observed in 35 (53%) cycles and in 20 (30%) cycles there were two‐three mature follicles. A multifollicular response (>3 mature follicles) resulted in 11 (17%) cycles. One of the 66 cycles was complicated with the ovarian hyperstimulation syndrome. Twelve (22%) pregnancies were obtained following 55 completed cycles. All ongoing pregnancies were singleton gestations. The obese PCOS women required a longer period of stimulation and a higher amount of gonadotropin to achieve follicular maturation. However, there was no difference in cycle cancellation or pregnancy rate between obese and non‐obese PCOS women. Thus low‐dose FSH administration seems a safe stimulation regimen with a satisfactory conception rate in PCOS women.

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