Early mechanism of action of arterially infused alcohol U.S.P. in renal devitalization.

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Abstract
Ten canine kidneys were infused transarterially with alcohol USP by injection into the renal artery at a rate equal to that of normal arterial blood flow. The kidneys were harvested at varying intervals following alcohol injection and examined by light and electron microscopy. The changes found were consistent with direct cellular toxicity rather than thrombosis-induced hypoxia. [Embolic devitalization of the kidney is often used in the treatment of patients with renal carcinoma.].

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