Differentiation between the effects of T1 and T2* shortening in contrast-enhanced MRI of the breast

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Abstract
The purpose of this study is to describe a technique for magnetic resonance imaging (MRI) that can potentially improve identification of malignant tissue in the human breast. The suggested MRI technique is based on the differentiation between two competing effects leading to opposite changes in image intensity, namely, T1 and T2* shortening caused by administration of gadolinium chelate. The proposed approach also allows calculation of changes in the R2* relaxation rate in breast tissue. The feasibility of the technique for in vivo MRI and increased lesion contrast is demonstrated. The results indicate that this technique may improve detection of malignant breast tissue. J. Magn. Reson. Imaging 1999;9:172–176.