Effect of Cigarette Smoking on Coronary Blood Flow and Myocardial Metabolism

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Abstract
The effect of smoking on the heart has been a controversial subject. The present studies were undertaken to investigate the effect of cigarette smoking on the coronary flow, myocardial usage of oxygen and myocardial extraction of glucose, pyruvate, lactate, and ketones. Catheterization of the coronary sinus revealed that cigarette smoking in patients without heart disease results in a significant rise in coronary blood flow and heart rate and a significant decline in coronary vascular resistance and myocardial extraction of oxygen and glucose. No evidence of coronary vascular constriction was detected.