Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways
- 22 August 1986
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 233 (4766) , 859-866
- https://doi.org/10.1126/science.3755548
Abstract
A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.Keywords
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