Sheep erythrocyte rosette formation and phytohemagglutinin-stimulated cells. Two cases of mycosis fungoides with skin tumors and lymph nodes
- 1 July 1979
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 115 (7) , 847-850
- https://doi.org/10.1001/archderm.115.7.847
Abstract
Infiltrating cells were harvested by mechanical means from [human] skin tumors and lymph nodes of myocis fungoides. Sheep erythrocyte rosette formation was observed on more than 90% of small lymphocyte-like cells with irregular nuclei but seemed to be hardly detectable on larger cells. The small and large cells that formed erythrocyte rosettes showed similar basic ultrastructures, which suggested that these 2 types of cells were of the same origin. When cultured with phytohemagglutinin (PHA), 90% of the small cells underwent transformation, and they were lymphoblast-like cells with irregular nuclei by EM. Only 40% of the large cells were transformed with PHA.This publication has 2 references indexed in Scilit:
- Cutaneous T-Cell Lymphomas: The Sézary Syndrome, Mycosis Fungoides, and Related DisordersAnnals of Internal Medicine, 1975
- Preferential Cutaneous Infiltration by Neoplastic Thymus-Derived LymphocytesAnnals of Internal Medicine, 1974