Restoration of excitation—contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA
- 1 November 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 336 (6195) , 134-139
- https://doi.org/10.1038/336134a0
Abstract
Microinjection of an expression plasmid that carries complementary DNA encoding the receptor for dihydropyridine calcium channel blockers of skeletal muscle restores both excitation-contraction coupling and slow calcium current in cultured skeletal muscle cells from mice with muscular dysgenesis. This suggests that the dihydropyridine receptor in the transverse tubule membrane of skeletal muscle functions both as the voltage sensor for excitation-contraction coupling and as the slow calcium channel.Keywords
This publication has 49 references indexed in Scilit:
- Calcium currents, charge movement and dihydropyridine binding in fast‐ and slow‐twitch muscles of rat and rabbit.The Journal of Physiology, 1987
- Primary structure of the receptor for calcium channel blockers from skeletal muscleNature, 1987
- Involvement of dihydropyridine receptors in excitation–contraction coupling in skeletal muscleNature, 1987
- Existence of distinct sodium channel messenger RNAs in rat brainNature, 1986
- Three types of neuronal calcium channel with different calcium agonist sensitivityNature, 1985
- Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.The Journal of general physiology, 1985
- Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequenceNature, 1984
- Calcium release from the sarcoplasmic reticulumPhysiological Reviews, 1977
- Contractile activation in skeletal muscleProgress in Biophysics and Molecular Biology, 1976
- Voltage Dependent Charge Movement in Skeletal Muscle: a Possible Step in Excitation–Contraction CouplingNature, 1973