Polyene Macrolactam Construction Using a Stille Vinyl-Vinyl Coupling Protocol: An Approach to the Antitumour Antibiotic Substance Leinamycin
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (03) , 215-216
- https://doi.org/10.1055/s-1993-22407
Abstract
A new approach to polyene macrolactam construction is described, based on an intramolecular Stille vinyl-vinyl coupling strategy, e.g. (10) → (12). The methodology is then applied to a synthesis of the macrolactam unit (17) found in the antitumour antibiotic substance leinamycin (1).Keywords
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