Studies on Agents with Vasodilator and .BETA.-Blocking Activities. I.
- 1 January 1994
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 42 (8) , 1609-1616
- https://doi.org/10.1248/cpb.42.1609
Abstract
A series of hydrazinopyridazine derivatives combined with a beta-blocking side chain were synthesized. When they were given intravenously to anesthetized rats, some of them exhibited both hypotensive and beta-blocking activities. Their structure-activity relationships for hypotensive and beta-blocking activities are discussed. Compound 11c had the best profile and was selected for further study.Keywords
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