Oral administration of liposomally-entrapped heparin to beagle dogs.

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Abstract
The oral administration of heparin [an anticoagulant] alone or entrapped in liposomes was investigated. The prolongation of clotting time (a-PTT [activated partial thromboplastin time]) was observed after administration of heparin and attributed to an increase of heparin activity in the blood as a result of effective absorption from the intestine. The increase of heparin activity was promoted by entrapping heparin in liposomes, but not by mere addition of empty liposomes.