Novel Five‐Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis
- 5 January 2006
- journal article
- research article
- Published by Wiley in ChemBioChem
- Vol. 7 (1) , 165-173
- https://doi.org/10.1002/cbic.200500321
Abstract
A novel 5‐membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein‐processing α‐glucosidase with a Ki value of 53 nM. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN‐2), human SARS coronavirus, and human β‐hexosaminidase (Ki=2.6 nM), a new target for the development of osteoarthritis therapeutics.Keywords
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