Secretion of Growth Hormone (GH)-Releasin Hormone by GH-Producing Pituitary Adenoma Assessed by Cell Immunoblot Analysis.

1 January 1995

journal article
Published by Japan Endocrine Society in Endocrine Journal

Vol. 42 (1) , 89-93
https://doi.org/10.1507/endocrj.42.89

Abstract

To detect growth hormone-releasing hormone (GHRH) secreted by monodispersed human GH-producing pituitary adenoma cells, the cell immunoblot assay was performed. GHRH-secreting cells were observed in 3 cases of GH-producing pituitary adenomas. The incidence of GHRH-secreting cells in the total cell populations was 0.24-3.42%. By contrast, no GHRH-secreting cells were observed in 2 cases of clinically nonfunctioning pituitary adenomas. The findings obtained by immunohistochemical studies for adenohypophysial hormones and for nuclear antigens of proliferative activity revealed that the incidence of GHRH-secreting cells is more related to the frequency of GH cells than to the proliferative activity in GH-producing pituitary adenomas.

Keywords

This publication has 0 references indexed in Scilit: