Role of l‐arginine in preventing myocardial and endothelial injury following ischaemia/reperfusion in the rat isolated heart
- 1 January 1996
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 156 (1) , 37-44
- https://doi.org/10.1046/j.1365-201x.1996.432152000.x
Abstract
The protective effect of l‐arginine on ischaemia/reperfusion‐induced myocardial injury was investigated in the rat isolated Langendorff perfused heart. Six groups of hearts subjected to 30 min global ischaemia and 30 min reperfusion received either vehicle, d‐arginine, l‐arginine, the nitric oxide (NO)‐donor S‐Nitroso‐N‐Acetyl‐d, l‐Penicillamine (SNAP), the inhibitor of NO formation NG‐nitro‐l‐arginine (l‐NNA), or l‐arginine plus l‐NNA. The recoveries of left ventricular double product and coronary flow at the end of reperfusion were significantly higher in the l‐arginine group (85±5 and 75±6%, respectively) than in the vehicle group (37±6 and 34±5%, respectively, PPper se but abolished the protective actions of l‐arginine. SNAP produced the same protective effects as l‐arginine. Acetylcholine‐induced endothelium‐dependent vasodilation was reduced after ischaemia and reperfusion in the vehicle group but not in the l‐arginine group. It is concluded that l‐arginine reduces ischaemia/reperfusion‐induced myocardial and endothelial injury. The results suggest that the beneficial effects of l‐arginine are related to preserved synthesis and release of NO.Keywords
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