Severe respiratory syncytial virus infection among otherwise healthy prematurely born infants: What are we trying to prevent?

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Abstract
Prematurity with or without bronchopulmonary dysplasia (BPD) is a recognized risk factor for severe lower respiratory tract infection (LRTI) due to respiratory syncytial virus (RSV) (1–3). Since 1993, three randomized placebo controlled trials have been published indicating that the rate of hospitalization for RSV LRTI is significantly reduced by monthly immunoprophylaxis during the annual RSV outbreak season (4–6). Immunoprophylaxis products are now available on a limited basis in Canada. This article presents Canadian data, gathered by the Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study group, on premature infants considered eligible for prophylaxis.

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