Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors
- 1 August 2006
- journal article
- Published by American Society of Hematology in Blood
- Vol. 108 (3) , 878-885
- https://doi.org/10.1182/blood-2005-11-4545
Abstract
Current models predict that mouse plasmacytoid dendritic cells (PDCs) derive from lymphoid progenitors. However, we show PDCs arise exclusively from common myeloid progenitors (CMPs) characterized by low-level expression of several lymphoid-associated genes, including a RAG2/GFP reporter transgene. This conclusion is supported by both adoptive transfer experiments and an estrogen treatment strategy that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP+ CMPs or the developmental kinetics, RAG-mediated recombinase activity, and cytokine production of PDCs. These data suggest that PDCs arise exclusively from early myeloid progenitors and that promiscuous low-level expression of lymphoid-associated genes is a general feature of PDC progenitors among CMPs.Keywords
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