Inhibition of Calcium Uptake by Somatostatin in Isolated Rat Islets of Langerhans
- 1 September 1976
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 99 (3) , 910-913
- https://doi.org/10.1210/endo-99-3-910
Abstract
Somatostatin (1 .mu.g/ml) inhibited glucose (16.7 mM)-stimulated 45Ca uptake by isolated rat islets incubated in media containing no added Ca or Ca at a low concentration (0.2 mM). Epinephrine (50 .mu.g/ml) and mannoheptulose (20 mM) inhibited 45Ca uptake by islets incubated in the presence of Ca (0.2 mM). Addition of glucose (16.7 mM) caused a small but significant increase in insulin release from islets incubated in media containing no added Ca. In the presence of a low concentration of Ca (0.2 mM), glucose caused a much greater increase in insulin secretion which was inhibited by addition of somatostatin, epinephrine or mannoheptulose.This publication has 3 references indexed in Scilit:
- An adrenergic receptor mechanism for the control of cyclic 3′5′ adenosine monophosphate synthesis in tissuesBiochemical and Biophysical Research Communications, 1967
- Method for the Isolation of Intact Islets of Langerhans from the Rat PancreasDiabetes, 1967
- Cation Requirements for Insulin Secretion in the Isolated Perfused PancreasDiabetes, 1966