Effect of Aging on the Frequency of Metaphase Chromosome Aberrations in the Liver of the Chinese Hamster

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Abstract
The chromosome aberration frequency in the liver of 148 Chinese hamsters was determined at various time intervals from animals 78 to 1100 days of age. A linear increase in the aberration frequency with age was described by the equation Y = 0.44 + 0.016 X where Y is the percentage of abnormal cells, X is age in days, 0.44 is the intercept, and 0.016 is the aberration coefficient expressed as percentage of abnormal cells per day. The slope of the line was about equal to that seen in guinea pigs. Both chromosome and chromatid types of aberrations were noted with isochromatid deletions and dicentrics being the most frequent. The background level of metaphase aberrations in young Chinese hamsters was low, making it possible to detect small changes. Since the frequency of chromosome aberrations changes with age, such data are necessary to form a baseline for lifetime studies with a variety of toxic agents.

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