Precursor cell types in the germinal zone of the cerebral cortex
- 1 May 1995
- Vol. 17 (5) , 391-393
- https://doi.org/10.1002/bies.950170506
Abstract
Retroviral lineage tracing experiments suggest that the cortical ventricular zone is composed of a mixture of precursor cell types. The majority generate a single cell type (neurones, astrocytes or oligodendrocytes) and the remainder generate neurones and a single type of glial cell. Pluripotential precursor cells, that have the ability to generate all three cell types, are not observed. A recent paper, however, reports that when single ventricular zone cells are cultured in isolation, a small percentage of these cells are pluripotential(1). This review will discuss what this knowledge tells us about cortical development.Keywords
This publication has 18 references indexed in Scilit:
- The Specification of Neuronal Fate: A Common Precursor for Neurotransmitter Subtypes in the Rat Cerebral Cortex In VitroEuropean Journal of Neuroscience, 1995
- Dispersion of neural progenitors within the germinal zones of the forebrainNature, 1993
- Diverse Migratory Pathways tn the Developing Cerebral CortexScience, 1992
- Widespread Dispersion of Neuronal Clones Across Functional Regions of the Cerebral CortexScience, 1992
- Separate Progenitor Cells Give Rise to Pyramidal and Nonpyramidal Neurons in the Rat TelencephalonCerebral Cortex, 1991
- The generation of neurons and oligodendrocytes from a common precursor cellNeuron, 1991
- Lineage-independent determination of cell type in the embryonic mouse retinaNeuron, 1990
- Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a Recombinant RetrovirusNeuron, 1988
- A common progenitor for neurons and glia persists in rat retina late in developmentNature, 1987
- Cell proliferation and migration in the primitive ependymal zone; An autoradiographic study of histogenesis in the nervous systemExperimental Neurology, 1959