Biologically active metabolites from Agelas mauritiana
- 1 January 1988
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 66 (1) , 45-50
- https://doi.org/10.1139/v88-006
Abstract
Two novel bicyclic diterpenoids, agelasimine-A (9), and agelasimine-B (10), have been isolated from the orange sponge Agelas mauritiana. Also, a new bromine-containing alkaloid, 5-debromomidpacamide (12), along with midpacamide (13) and methyl N-methyl-4,5-dibromopyrrole-2-carboxylate (11), has been isolated. The structures were determined by interpretation of their spectral data. Agelasimine-A- and -B exhibit a wide range of interesting biological activities such as cytotoxicity, inhibition of adenosine transfer into rabbit erythrocytes, Ca2+-channel antagonistic action, and .alpha.1 adrenergic blockade.Keywords
This publication has 1 reference indexed in Scilit:
- Antimicrobial metabolites from a Pacific sponge, Agelas spJournal of the American Chemical Society, 1984