Degradation Radio-induite de la Thymidine en Solution Aqueuse Désaérée
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 39 (2) , 119-133
- https://doi.org/10.1080/09553008114550141
Abstract
The steady-state .gamma. radiolysis of deaerated aqueous solutions of thymidine generated a complex mixture of pyrmidine and nucleoside derivatives. Of these compounds, 22 were isolated and characterized by spectroscopic methods including proton NMR and mass spectrometry. The major 5,6-saturated products were identified as the 5R and 5S diasteroisomers of 5,6-dihydrothymidine and their mono and dihydroxylated derivatives on the 5 and/or 6-carbons. The G values of these various compounds were determined. The roles of the primary reactive species derived from the radiolysis of water were studied by using specific radical scavengers, i.e., ethanol, t-butanol and potassium nitrate.This publication has 43 references indexed in Scilit:
- Radiosensibilisation de la thymine en presence de tetramethyl-2,2,6,6 piperidone-4 oxyle-1. caracterisation des produits d'additionTetrahedron, 1979
- Preparation, isomerisation et configuration absolue des “hydrates” de thymidineTetrahedron, 1977
- Techniques de remplissage de colonnes de chromatographie liquide à haute performance avec des microparticules poreusesJournal of Chromatography A, 1975
- Isomerization and new specific synthesis of thymine glycolTetrahedron, 1975
- Irradiation gamma de la thymine en milieu desaere: Isomères cis et trans de l'hydroxy-6 dihydro-5,6 thymineThe International Journal of Applied Radiation and Isotopes, 1971
- Pulse-radiolysis and flash-photolysis study of aqueous solutions of simple pyrimidines. Uracil and bromouracilThe Journal of Physical Chemistry, 1968
- A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solutionThe International Journal of Applied Radiation and Isotopes, 1967
- Thymine Addition to Ethanol: Induction by Gamma IrradiationScience, 1966
- Nonclassical Antimetabolites. XXV.1 Inhibitors of Thymidine Kinase. I. A New Spectrophotometric Assay. Inhibition by Nucleoside DerivativesJournal of Medicinal Chemistry, 1966
- The Catalytic Hydrogenation of Pyrimidine Nucleosides and Nucleotides and the Isolation of their Ribose and Respective Ribose Phosphates1,2Journal of the American Chemical Society, 1956