THE EFFECTS OF PROSTAGLANDIN E1, BRADYKININ AND HISTAMINE ON CANINE SYNOVIAL VASCULAR PERMEABILITY
Open Access
- 1 June 1977
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 60 (2) , 251-254
- https://doi.org/10.1111/j.1476-5381.1977.tb07747.x
Abstract
1 The relative effects of prostaglandin E1, bradykinin and histamine on canine synovial vascular permeability were investigated by a method based on the measurement of the amounts of radiolabelled dextran (molecular weight 20,000) leaking from the circulation into the synovial cavity. 2 Bradykinin, prostaglandin E2 and histamine in that order of potency all increased synovial vascular permeability. Threshold concentrations were 0.3 μM, 3 μM and 30 μM respectively. 3 The effects of infusion of prostaglandin E1 combined with either bradykinin or histamine were greater than mere summation.Keywords
This publication has 10 references indexed in Scilit:
- STUDIES ON THE RELATIVE EFFECTS OF PROSTAGLANDINS, BRADYKININ, 5‐HYDROXYTRYPTAMINE AND HISTAMINE ON THE SYNOVIAL MICROCIRCULATION IN DOGSBritish Journal of Pharmacology, 1976
- ON THE ABILITY OF PROSTAGLANDIN E1 AND ARACHIDONIC ACID TO MODULATE EXPERIMENTALLY INDUCED OEDEMA IN THE RAT PAWBritish Journal of Pharmacology, 1975
- Proceedings: Potentiation by prostaglandins of the nociceptive activity of bradykinin in the dog knee joint.1974
- Prostaglandins, Aspirin-like Drugs and the Oedema of InflammationNature, 1973
- Prostaglandins as Potentiators of Increased Vascular Permeability in InflammationNature, 1973
- PROSTAGLANDIN E1: A POTENTIAL MEDIATOR OF THE INFLAMMATORY RESPONSEAnnals of the New York Academy of Sciences, 1971
- Plasma Kinin Formation in Rheumatoid ArthritisPublished by Springer Nature ,1970
- The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologiesArthritis & Rheumatism, 1967
- Electron microscopic observations on the rheumatoid synovial membraneArthritis & Rheumatism, 1966
- BradykininAmerican Heart Journal, 1961