Some characteristics of blood in normal and immune rabbits after urease injection

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Abstract
Weekly intravenous (iv) injections (2 U/kg body weight) of crystalline jackbean urease reduced circulating white cells (WBC), hematocrit, and hemoglobin of rabbits for 48 hr. after injection. The average WBC, hematoctir, and hemoglobin was depressed 5 hr. after the 1st injection and remained depressed throughout the 4-week period of urease injection. Neither blood ammonia nor urea were affected after the 1st week. Antiurease was detectable at a serum dilution of 1:100, 24 hr. after the first iv injection and in 1: 500 dilution at 48 hr. In all experiments, active or passive immunity against jackbean urease significantly reduced the magnitude of the changes seen after urease injection. Antiserum from rabbits immunized by weekly iv injections protected mice against dosages of urease far in excess of the LD99.

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