SERUM, URINE AND PERITONEAL-FLUID LEVELS OF 5-FU FOLLOWING INTRAPERITONEAL ADMINISTRATION

  • 1 July 1987
    • journal article
    • research article
    • Vol. 7  (4) , 829-832
Abstract
Seven patients with advanced colon cancer, refractory to conventional chemotherapy, and malignant disease confined to the intra-abdominal space received a total of 24 consecutive courses of ip 5-Fluorouracil (5-FU). 5-FU 1000 mg was administered in 2 L of warm (37.degree. C) dialysate daily for five consectuve days every 28 days. 5-FU concentrations in serum, peritoneal fluid and urine were measured by high pressure liquid chromatography (HPLC). The mean disappearance half-life of 5-FU from the peritoneal fluid was 1.6 hours with a mean permeability area product (PA) of 22.4 ml/min. The mean peritoneal AUC was 450 .+-. 165 times greater than the mean serum AUC. Ip 5-FU treatment is well tolerated, can be safely administered on an outpatients basis and produces a significant pharmacological advantages over conventional routes of administration.