BONE KINETICS OF CA-45 AND PYROPHOSPHATE LABELED WITH TECHNETIUM-96 - AN AUTORADIOGRAPHIC EVALUATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (5) , 466-470
Abstract
The uptake of 45Ca and of pyrophosphate labeled with the long-lived 99Tc isotope were compared by means of liquid-emulsion microautoradiograms of the epiphyseal plates of 10 wk old rabbits, at 30 min, and 3 and 48 h after i.v. administration. For both tracers, thin sections confirm the significant role of the blood supply, especially shortly after injection. Other more specific mechanisms lead to a mixing of the Ca in the mineral mass and to a linear deposition of Tc facing the osteoid surfaces. Apparently, the tropism of tin-reduced technetium pyrophosphate is not governed by the mineral pool but by exchanges inside a still poorly calcified organic matrix.

This publication has 0 references indexed in Scilit: