COMPARISON OF 19-IODOCHOLESTEROL AND 6-IODOMETHYINORCHOLESTEROL AS ADRENAL-SCANNING AGENTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (7) , 724-727
Abstract
The 2 adrenal-specific compounds, 19-iodocholest-5-en-3.beta.-ol (19-iodocholesterol) and 6.beta.-iodomethyl-19-norcholest-5(10)-en-3.beta.-ol (6-iodomethylnorcholesterol), synthesized pure in gram amounts were labeled with 125I and used for tissue-distribution studies in the rat. Radioactivity from 6-iodomethylnorcholesterol is accumulated in the rat adrenal gland at least 18 times more than is radioactivity from 19-iodocholesterol at 24 h, and 50 times more at 72 h. The use of radioactive 6-iodomethylnorcholesterol gave superior adrenal images in rats at earlier times than did radioactive 19-iodocholesterol, and the former should be equally superior when used in humans.

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