Control of Dose Administered Once a Week and Three Times a Day According to Schedules Calculated by the CRE Formula, Using Skin Reaction as a Biological Parameter

1 August 1976

journal article
research article
Published by Radiological Society of North America (RSNA) in Radiology

Vol. 120 (2) , 399-404
https://doi.org/10.1148/120.2.399

Abstract

Patients with breast cancer were irradiated postoperatively to bilateral parasternal fields. The validity of the cumulative radiation effect (CRE) formula for treatment once a week and 3 times a day was analyzed, and both schedules were compared with treatment once a day (4 times a week). The biological radiation effect on normal tissue was studied by reflectance spectrophotometry of skin erythema and pigmentation. Early skin reactions were identical after irradiation daily and once a week, respectively, but were significantly more pronounced after irradiation 3 times a day than after treatment once a day, corresponding to an overexposure of 7-10%.

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