Evidence for a Pituitary Site of Action for the Acute Inhibition of LH Release by Estrogen in the Rat

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Abstract
Intravenous administration of estradiol in doses of 20 ng or more was capable of inhibiting LH release in ovariectomized rats as indicated by a decrease in plasma LH determined by radioimmunoassay. The inhibition came on within 1 hr and could persist for up to 4 hr after a single injection. The decrease in plasma LH which followed the injection of estradiol was at least in part caused by a decreased sensitivity of the pituitary gland to LRF since the increment in plasma LH in response to injection of the synthetic decapeptide was significantly decreased in estradiol—treated animals. Endocrinology92: 1680, 1973)

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