A NEW CONCEPT IN THE STABILIZATION OF INJECTABLE FLUOROCARBON EMULSIONS: THE USE OF MIXED FLUOROCARBON-HYDROCARBON DOWELS.
- 1 June 1992
- journal article
- research article
- Published by Taylor & Francis in Journal of Dispersion Science and Technology
- Vol. 13 (3) , 349-355
- https://doi.org/10.1080/01932699208943319
Abstract
A new means of stabilizing fluorocarbon in water emulsions is reported. It uses mixed fluorocarbon/hydrocarbon amphiphiles, acting as molecular dowels, to reinforce the binding between the fluorocarbon phase and its surrounding lipidic membrane. In an example, perfluorooctylbromide/phospholipid emulsions (90/4 % w/v) stabilized by C8F17CH=CHC8H17 (2.8 % w/v) remain stable, with no significant increase in particle sizes (after the initital equilibration period) for 9 months at 40°C.Keywords
This publication has 3 references indexed in Scilit:
- Liver, spleen, and vessels: preliminary clinical results of CT with perfluorooctylbromide.Radiology, 1989
- An Overview of Perfluoroctylbromide—Application as a Synthetic Oxygen Carrier and Imaging Agent for X-Ray, Ultrasound and Nuclear Magnetic ResonanceBiomaterials, Artificial Cells and Artificial Organs, 1988
- Preparation and Application of Highly Concentrated Perfluoroctylbromide Fluorocarbon EmulsionsBiomaterials, Artificial Cells and Artificial Organs, 1988