Effects of captopril (SQ 14,225) in a patient with primary pulmonary hypertension
Open Access
- 1 February 1981
- journal article
- case report
- Published by Oxford University Press (OUP)
- Vol. 57 (664) , 115-116
- https://doi.org/10.1136/pgmj.57.664.115
Abstract
Summary: In a 33-year-old patient with severe primary pulmonary hypertension, the acute administration of the angiotensin-converting-enzyme inhibitor captopril (SQ 14,225) induced a rise in cardiac output, and a fall in both pulmonary and systemic vascular resistance. Subsequent chronic oral administration of captopril induced only transient clinical improvement, and the patient died. Captopril may nevertheless be useful in the treatment of less advanced cases of this disease.Keywords
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