Experimental cerebral vasospasm: Resolution by iloprost
- 1 September 1988
- journal article
- research article
- Published by Springer Nature in Acta Neurochirurgica
- Vol. 95 (3-4) , 131-135
- https://doi.org/10.1007/bf01790774
Abstract
A new stable analogue of prostacyclin, iloprost, was tested on the basilar artery of anaesthetized rabbits constricted by electrical stimulation and intracisternal injection of autologous blood. The vasospasm induced by these stimuli was effectively relieved (about 100%) by topical application of iloprost, a stable analogue of prostacyclin (PGI2), and no constriction occurred on further stimulation within one hour. The mechanisms of the action of iloprost and its possible therapeutic value in subarachnoid haemorrhage are discussed.Keywords
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