Functional Magnetic Resonance Imaging Assessment of the Human Brain Auditory Cortex Response to Increasing Word Presentation Rates
- 1 January 1997
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 77 (1) , 476-483
- https://doi.org/10.1152/jn.1997.77.1.476
Abstract
Dhankhar, Ajay, Bruce E. Wexler, Robert K. Fulbright, Terry Halwes, Andrew M. Blamire, and Robert G. Shulman. Functional magnetic resonance imaging assessment of the human brain auditory cortex response to increasing word presentation rates. J. Neurophysiol. 77: 476–483, 1997. In an investigation of the auditory cortex response to speech, six subjects were studied using echo-planar functional magnetic resonance imaging (fMRI) at 2.1T. The subjects were asked to listen to English nouns presented at various rates ranging from 0 words per minute (wpm) to 130 wpm while fMRI images encompassing their primary and posterior superior secondary auditory cortices were acquired. An asymmetric spin echo imaging sequence was used with an induced T2 weighting of 50 ms to allow for transverse relaxation effects. Images were acquired in two or four axial-oblique slices with a repetition time of 3.75 or 7.5 s, in plane resolution of 6 × 3 mm, and a slice thickness of 5 mm. Localized activation centered over grey matter was consistently observed in all subjects in the transverse temporal gyrus (TTG), the transverse temporal sulcus (TTS), and the posterior superior aspect of the superior temporal gyrus (STG). The total activated volume and the integrated signal response in bilateral primary and posterior superior secondary auditory cortices increased with increasing rate of word presentation, peaking at 90 wpm (with some intersubject variability) with a subsequent fall at 130 wpm. There were no significant differences in the rate dependence of the signal response in bilateral primary and bilateral posterior superior secondary auditory cortices (P < 0.05).Keywords
This publication has 21 references indexed in Scilit:
- Effects of stimulus rate on signal response during functional magnetic resonance imaging of auditory cortexCognitive Brain Research, 1994
- Functional magnetic resonance imaging of human auditory cortexAnnals of Neurology, 1994
- Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging.Proceedings of the National Academy of Sciences, 1992
- Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.Proceedings of the National Academy of Sciences, 1992
- Activation of the Human Auditory Cortex by Speech SoundsActa Oto-Laryngologica, 1991
- Stimulus rate determines regional brain blood flow in striate cortexAnnals of Neurology, 1985
- Tonotopic organization in human auditory cortex revealed by positron emission tomographyHearing Research, 1985
- Cytoarchitectonic organization of the human auditory cortexJournal of Comparative Neurology, 1980
- WERNICKE'S REGION–WHERE IS IT?Annals of the New York Academy of Sciences, 1976
- ORGANIZATION OF AUDITORY CORTICAL AREAS IN MANBrain, 1976