Asymmetric synthesis of α-substituted o-methoxybenzyl alcohols via stereoselective additions to kinetically resolved o-anisaldehyde(tricarbonyl)chromium
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 1,p. 192-194
- https://doi.org/10.1039/p19890000192
Abstract
Homochiral (+)-o-anisaldehyde(tricarbonyl)chromium, prepared by a kinetic resolution procedure involving selective hydrolysis of the diastereoisomeric L-valinol derived imines, undergoes completely stereoselective addition reactions with methyl- and ethyl-magnesium iodide to give enantiomerically pure (–)-(S)-1-(o-methoxyphenyl)ethanol and (–)-(S)-1-(o-methoxyphenyl)propanol.Keywords
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