Inhibition of P. falciparum growth in human erythrocytes by monoclonal antibodies

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Abstract
Malaria is increasing in incidence and prevalence in most tropical areas and is a major problem for individuals and communities. Current malaria research is aimed at developing vaccines and for this it may be useful to define Plasmodium antigen(s) related to the development of a protective immune response in the host. Monoclonal antibodies were recently shown to interfere with rodent malaria infection (P. berghei) at the sporozoite or merozoite stage. Monoclonal antibodies were raised against single antigenic determinant(s) of P. falciparum; some of them inhibit the growth of erythrocytic forms of P. falciparum in vitro.