DELAYED IMPLANTATION IN INTACT RATS TREATED WITH MEDROXYPROGESTERONE ACETATE

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Abstract
Intact, female Holtzman rats were treated daily with medroxyprogesterone acetate (MAP; Provera) in corn oil, beginning on the day of insemination. This caused delay of implantation in 14% (0.5 mg/day) to 100% (2.4 mg/day) of the animals tested. It is possible that MAP suppresses the synthesis or the release of luteinizing hormone (LH) from the pituitary gland and thus prevents the production of sufficient endogenous oestrogen to cause implantation. Implantation was achieved in "delayed" rats by simultaneous administration of 1 [mu]g of oestrone with the dose of MAP they had been receiving. The viability of foetuses in such animals varied inversely with the dose of MAP the mothers had received.

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